Lupine Publishers Pediatrics and Neonatology
Introduction
Coordinated manner of action of the projections from monoaminergic
cell groups, cholinergic and orexin neurons, produces arousal. Turning
this arousal system off would result in producing sleep. There is an
important role for the Ventrolateral Preoptic Nucleus (VLPO) to inhibit
the arousal circuits during sleep. VLPO neurons are sleep active neurons
[1-3]. Also, these neurons contain GABA and Galanin as inhibitory
neurotransmitters. Such neurons receive afferents from monoaminergic
systems. VLPO lesions would cause fragmented sleep and insomnia.
VLPO has two groups of neurons: One group located in the core of the
VLPO and its neurons project to the tuberomammillary nucleus and the
other group of neurons which is called extended VLPO, projects to the
median and dorsal raphe nuclei and locus coeruleus, tuberomammillary
nucleus and dorsal raphe as the arousal system components on one hand
and VLPO on the other hand would be inhibitory in the mutual manner
[4-6]. This results in a flip-flop electronic switch or circuit. This
flip-flop design, prevents intermediate states to be occurred,
facilitates switching between states of behavior and ensures behavioral
states stability [7]. Such flip-flop design causes the monoaminergic
system to be on the arousal side and the VLPO to be on the sleeping
side.
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